Name | Myrislignan |
Synonyms | Myrislignan Nutmeg lignan (-)-erythro-(7R,8S)-8'-4,7-dihydroxy-3,3',5'-triMethoxy-8-O-4'-neolignan (aR)-alpha-[(1S)-1-[2,6-Dimethoxy-4-(2-propen-1-yl)phenoxy]ethyl]-4-hydroxy-3-methoxybenzenemethanol Benzenemethanol, α-[(1S)-1-[2,6-dimethoxy-4-(2-propen-1-yl)phenoxy]ethyl]-4-hydroxy-3-methoxy-, (αR)- 1-(4-benzoylpiperazin-1-yl)-2-[4-fluoro-7-(3-phenyl-1,2,4-oxadiazol-5-yl)-1H-indol-3-yl]ethane-1,2-dione |
CAS | 171485-39-5 |
Molecular Formula | C21H26O6 |
Molar Mass | 374.43 |
Density | 1.167 |
Boling Point | 537.6±50.0 °C(Predicted) |
Solubility | Soluble in methanol, ethanol, DMSO and other organic solvents |
Appearance | White powder |
pKa | 9.94±0.31(Predicted) |
Storage Condition | 2-8℃ |
MDL | MFCD13195532 |
Physical and Chemical Properties | Colorless crystals, soluble in methanol, ethanol, DMSO and other organic solvents, derived from nutmeg. |
application | nutmeg lignans have anti-inflammatory effects and can be used in the process of laboratory research and development of medicine, mainly as an analysis reference substance. |
biological activity | Myrislignan is a lignan isolated from Myristica fragrans Houtt and has anti-inflammatory activity. Myrislignan can inhibit interleukin-6 (IL-6) and tumour necrosis factor-α (TNF-α). Myrislignan dose-dependently inhibited the expression of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2) in LPS-stimulated macrophages. Myrislignan can inhibit the activation of NF-κB signaling pathway. |
Target | Value |
use | nutmeg lignans have anti-inflammatory effects. used for content determination/identification/pharmacological experiment, etc. |